Some 100 members of staff at the Shaw Trust could lose their jobs as the charity restructures.
The redundancies are part of a strategic review of structure, management and performance by Chris Luck, who was appointed chief executive in February.
In a statement, the charity said it aims to maximise the benefits of Shaw Trust’s acquisition of Prospects Services and Ixion Holdings, which merged with the charity in 2017.
“The majority of these changes will mostly affect corporate roles and functions with the focus on delivering an efficient and effective platform that protects frontline services.”
Shaw Trust has an income of £250m and around 3,600 employees, according to its 2018 accounts filed with the Charity Commission.
The charity also plans to move its headquarters to South London.
Central support service operations at the disability charity’s current leased head offices in Bristol will relocate to Bromley when a break clause in the renting agreement takes effect next summer.
The Bromley offices were acquired as part of Shaw Trust's purchase of employment and skills company Prospects Services in 2017.
Luck said: “The goal is to ensure that we can maximise what we do for our beneficiaries on behalf of our commissioners, in a sustainable manner fit for the future.”