Scope is rolling out a scheme where donors loan or donate £50,000 to open a new Scope charity shop.
The scheme has been trialled in Cambridgeshire where eight people donated and lent £100,000 to open two stores.
The charity is now looking to roll the scheme out more widely, and aims to attract enough people to open up to 15 new shops by March 2013.
A Scope spokesman says each Scope store generates as much as £30,000 a year, which Scope can use as a source of on-going funding for its work. It also means that within two years a loan can be paid back.
The news comes as Scope announces that former River Island chief executive Richard Bradbury is to be a patron. The charity hopes his expertise will add to the success of the scheme.
Richard Hawkes, chief executive of Scope said: “We are making donations go much further. By helping us open a new shop, a supporter will see their donation triple in value in just five years. Scope is about making this a better place for disabled people – this new way of fundraising means we can run more campaigns and provide more services that help us achieve that vision.”